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Levels of Trace Elements and Antioxidant Vitamins in Type 2 Diabetic Patients in Ile-Ife, Nigeria

Fagbohun, Oladapo F. (2016) Levels of Trace Elements and Antioxidant Vitamins in Type 2 Diabetic Patients in Ile-Ife, Nigeria. Trends in Medical Research, 12. pp. 26-31. ISSN 1819-3587

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Abstract

Background: Levels of Zn, Cu, Mg, vitamin E and vitamin C were measured in 65 Nigerian diabetic subjects with and without micro vascular complications and compared with controls, in order to ascertain their association with the disease and its complications. Methods: Fasting blood glucose, glycated hemoglobin, Zn, Cu, Mg, vitamin E and vitamin C were assayed according to standard procedures. Statistical analysis was carried out using SPSS version 17.0. Results: Mean values of Zn, Mg and vitamin E were significantly higher (p<0.05) in control groups than diabetic subjects. The Zn levels correlated negatively with fasting blood glucose (p = 0.000, R = -0.443) and glycated hemoglobin (p = 0.030, R = -0.269) while Mg and vitamin E correlated negatively with fasting blood glucose (p = 0.000. R = -0.405 and p = 0.000, R = -0.524, respectively). The Zn, Mg and vitamin E levels correlated positively with each other. Diabetic subjects with retinopathy and nephropathy had significantly lower levels of vitamin E than others. Conclusion: Alterations in trace elements and vitamin status were observed in Nigerian diabetes mellitus subjects. The pattern differs from previous studies in respect of Cu and vitamin C levels. The alterations appear to be more as a result of diabetes itself, rather than being involved in the progression of the disease.

Item Type: Article
Uncontrolled Keywords: Diabetes mellitus, fasting blood glucose, glycated hemoglobin, trace elements, antioxidant vitamins
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Dr. Oladapo F. Fagbohun
Date Deposited: 23 Dec 2019 10:46
Last Modified: 23 Dec 2019 10:46
URI: http://ir.tech-u.edu.ng/id/eprint/514

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